Starting at $ 45,175. 6.5 / 10 C/D RATING. Specs. Photos. Lexus. Select a year. 2023 2022 2021 2020 2019 2018 2017. Highs Great real-world highway fuel economy, plenty of safety equipment, cushy .... 4. LEXUS RX 300 / 330 2004 Lexus RX330. 3. ACURA MDX 2007 Acura MDX. The model years in this study is 2001-2009. The highest record was 381,000 miles on a 2004 model with 3.5L V6. Furthermore 26% of MDX had more than 200,000 miles and three vehicles had more than 300,000 miles. There haven't been many issues recorded for this model. Joined Jul 11, 2007. ·. 163 Posts. #2 · Mar 16, 2011 (Edited) Only show this user. Probably because all RX300's are V6 AWD, the FWD and all I4 Highlander don't seem to be affected as much. So only 1/4 (theoretically, probably closer to 1/3 from what I see) have that drivetrain. Also, the weight might be an issue. "/>How many miles can a lexus rx300 last